Scott died after going through several surgeries, chemotherapy, radiation and clinical trials in his fight against cancer, the station said in a press release. He was diagnosed with cancer in 2007."ESPN and everyone in the sports world have lost a true friend and a uniquely inspirational figure in Stuart Scott," said ESPN president John Skipper. "Who engages in mixed martial arts training in the midst of chemotherapy treatments? Who leaves a hospital procedure to return to the set? His energetic and unwavering devotion to his family and to his work while fighting the battle of his life left us in awe, and he leaves a void that can never be replaced."
Scott is survived by his two daughters -- Taelor, 19, and Sydni, 15 -- and his girlfriend, Kristin Spodobalski, in addition to his parents O. Ray and Jacqueline Scott; and his three siblings Stephen Scott, Synthia Kearney and Susan Scott.
"Taelor and Sydni, I love you guys more than I will ever be able to express," Scott said in July while accepting the Jimmy V Perseverance Award at the ESPYs. "You two are my heartbeat. I am standing on this stage here tonight because of you."
Scott joined ESPN in 1993 and became a top voice on the channel's SportsCenter program, aided by his enthusiasm and colorful descriptions of sports stories, including catch phrases like "Boo-ya" and "As cool as the other side of the pillow."
He interviewed top figures inside and outside the world of sports, such as Tiger Woods, Michael Jordan, Denzel Washington and Presidents Barack Obama and Bill Clinton.
"Think about that phrase, 'As cool as the other side of the pillow.' It's a hot, stifling night. You're having trouble sleeping. But then you think to turn the pillow over, and, Wow, it's cool, and it feels so good," said Jay Harris, a SportsCenter anchor who grew up watching and idolizing Scott.
"Well, that's who Stuart is. He is 'the other side of pillow,' the man who made sportscasting cool. God bless whoever it was who thought to rearrange the bedding at ESPN," Harris added.
Scott covered major sporting events throughout his career, including the NBA Finals, the Super Bowl, MLB's World Series and the NCAA Final Four. He also starred in several This Is SportsCenter commercials.
"He didn't just push the envelope," said sports radio host and former ESPN anchor Dan Patrick. "He bulldozed it."
Scott raised hundreds of thousands of dollars for organizations dedicated to fighting cancer, such as The V Foundation and Livestrong, and he participated in Stand Up To Cancer campaigns, ESPN says.
Scott graduated from the University of North Carolina in 1987 and worked at local stations in Orlando, Raleigh, North Carolina and Florence, South Carolina, before joining ESPN.