The doctors went to Everest on a medical expedition, to learn about high altitude medicine, but they never reached the summit.
The quake trapped them in a remote area, their families were unable to speak with them for days.
The two snapped a picture before the quake on their way to Everest.
Days later a 7.8 earthquake rocked Nepal and caused a massive avalanche on Everest.
Thousands were killed, and then silence.
"When the earthquake hit, we had no communication," said Dr. Christina Reuss.
For hours Saturday she didn't know if her husband survived the catastrophic events.
"The most emotional part for me was going into an official website where I had to upload his passport and say that he was missing; that's really scary," said Dr. Reuss.
Now with her two sons, she had a different set of emotions.
"This week I have almost felt giddy with excitement," she said.
Excitement at the news her husband and his group were ok, this week she finally spoke with him via Facetime.
"It really makes a difference when I heard his voice saying we are good; I'm ok," said Reuss.
When the quake hit, the doctors were on a 10-hour trek to the Mount Everest Base Camp.
"What he did say was that they were asked to stay put, they felt the earthquake," she said.
Now the group has made it to Lukla, a town with a regional airport.
They're waiting to fly back to Katmandu; the city hit hardest by the quake.
And while Eric Reuss is anxious to get home, he told his family he is also ready to help the victims.
"Just him being there in helping support other physicians is relieving for him, and the other doctors that are there," said Reuss.
The family expects Eric and his group to make it back to the United States on Wednesday.