A police helicopter tracked the suspects to east valley, along the 202, and onto the U.S. 60 in Mesa.
Officers say the men inside were responsible for several armed robberies.
At one point they say they saw the suspects throwing guns out of the window, that is when pursuing officers backed off and let the helicopter chase.
Moments later officers used spike strips to disable the tires and when it approached Signal Butte on US 60 officers swarmed in and pulled two out of the car.
Investigators have not released the identity of the suspects.