The state's government and top politicians say it is time to take the flag down.
South Carolina Governor Nikki Haley is calling for the Confederate flag to be removed from the grounds of the state capitol, and she's been joined by a growing list of lawmakers.
And WalMart has announced it is removing all Confederate flag-themed items from all of its stores and online.
South Carolina's top Republican government officials, including the Governor and both Senators, called for the Confederate flag to be removed from the state house.
"Today we are here at a moment of unity in our state, it is time to remove the flag from the capitol grounds," said Governor Nikki Haley.
The flag blew up into a huge 2016 campaign issue when 2012 Republican Mitt Romney tweeted: "Take down the #ConfederateFlag at the SC Capitol. To many, it is a symbol of racial hatred. Remove it now to honor #Charleston victims."
Former Florida Governor Jeb Bush issued a statement on Saturday saying: "My position on how to address the Confederate flag is clear. In Florida, we acted, moving the flag from the state grounds to a museum where it belonged."
Former Arkansas Governor Mike Huckabee suggested the South Carolina flag issue is a trap. "For those of us running for President, everyone's being baited with this question as if somehow that has anything to do whatsoever with running for President. And my position is, it most certainly does not."
Democratic candidate Hillary Clinton's campaign said she has been against the flag since 2007 when she called for it being removed from the statehouse grounds.
Bernie Sanders and Martin O'Malley, also contenders for the Presidency, say the flag belongs in a museum.
WalMart issued a statement as follows, "We never want to offend anyone with the products that we offer. We have taken steps to remove all items promoting the confederate flag from our assortment, whether in our stores or on our website," "We have a process in place to help lead us to the right decisions when it comes to the merchandise we sell. Still, at times, items make their way into our assortment improperly, this is one of those instances."
Following Haley's announcement, a number of GOP candidates have expressed support for her decision.