Police say it started around 6 p.m. when a speeding car went through a red light heading west on southern and T-boned an SUV with a mother and three kids inside.
After hitting the SUV, the car eventually slammed into a pole.
It's unclear how the other cars were involved in the wreck, but at least four people were taken to the hospital.
Among the injured is a 7-year-old girl; she was ejected from the SUV. She was taken to Phoenix Children's Hospital in extremely critical condition.
We're told she wasn't wearing a seat belt at the time.
One man who saw the crash says he saw the child get ejected from the vehicle and stopped to help.
"I was in the turning lane. I seen the little girl ejected, so I ran to her aid. I took my shirt off and I put it over her head cause she was bleeding, and she had a big old split open right and her skull was open and she was just bleeding out, so I took my shirt off and put it on her and tried to stop the bleeding," said the witness.
The driver who ran the red light was also taken to the hospital, but we're not sure of their condition at this point.
In addition, we're told a man in his 20's and a man in his 50's were also hospitalized. An 8-year-old boy had minor injuries and was treated at the sceneThe intersection was shutdown well into the night while crews investigated.
It's unclear at this point whether drugs or alcohol were a factor in the crash or whether red light runner will face any charges.
This is a developing story. Stay with FOX 10 News for updates.