The two cars collided near 28th Street and Earll Drive around 1:00 p.m., according to Capt. Benjamin Santillan with the Phoenix Fire Department.
Santillan tells Fox 10 News that emergency medical responders had to extricate one person from one of the cars involved in the crash.
One man was then transported to the hospital in extreme critical condition, Santillan said.
Another man and a 3-year-old child were also transported to the hospital in serious condition.
Phoenix police are still trying to determine the cause of the crash.
Fox 10 News will continue to monitor this story and provide updates as they become available.