PHOENIX (AP/KSAZ) -- John McCain, the six-term Arizona senator and the Republican presidential nominee in 2008, has chosen to discontinue medical treatment for his brain cancer, his family said Friday.
Statement from the McCain family:
"Last summer, Senator John McCain shared with Americans the news our family already knew: he had been diagnosed with an aggressive glioblastoma, and the prognosis was serious. In the year since, John has surpassed expectations for his survival. But the progress of disease and the inexorable advance of age render their verdict. With his usual strength of will, he has now chosen to discontinue medical treatment. Our family is immensely grateful for the support and kindness of all his caregivers over the last year, and for the continuing outpouring of concern and affection from John's many friends and associates, and the many thousands of people who are keeping him in their prayers. God bless and thank you all."
The senator, who will be 82 next week, has been away from the Capitol since December. If he should resign his seat or die soon, Republican Arizona Gov. Doug Ducey would name a replacement, who would serve out the remainder of McCain's term -- through the 2020 election. The GOP currently holds a bare 51-49 Senate majority.
The son and grandson of Navy admirals, McCain is a former Navy pilot and was held as a prisoner of war in Vietnam for more than five years. He was elected to Congress in the early 1980s and elected to the Senate in 1986, replacing Barry Goldwater who retired. McCain gained a reputation as a lawmaker who was willing to stick to his convictions rather than go along with party leaders. It is a streak that draws a mix of respect and ire.
He has been a frequent target of criticism from President Donald Trump, especially for his vote against a Republican replacement for "Obamacare," the health care law approved under President Barack Obama.
Trump signed a military policy bill this month named for McCain, but in a sign of their testy relationship the president made no mention of McCain's name in remarks at a signing ceremony.
Senate Majority Leader Mitch McConnell said on Twitter that he was "very sad to hear this morning's update" from McCain's family.
"We are so fortunate to call him our friend and colleague. John, Cindy, and the entire McCain family are in our prayers at this incredibly difficult hour," McConnell said.
Arizona Gov. Ducey called McCain "an American hero" who always put his country before himself.
Ducey said a "spirt of service and civility" guided McCain's life, standing as a model for Americans regardless of political affiliation.
Meanwhile, Arizona Senator Jeff Flake, who stopped by FOX 10 Friday to talk about the announcement, said he believes the family is at peace with the decision.
"They are, most definitely, but I expressed to the family and him the appreciation for him speaking out this year, even during this difficult time," said Sen. Flake. "Even with the tough treatments he was going through and everything he had to deal with, he still stayed current on events and spoke out when he needed to be the conscience of the Senate."
McCain's wife, Cindy, tweeted: "I love my husband with all of my heart. God bless everyone who has cared for my husband along this journey."
McCain underwent surgery in July 2017 to remove a blood clot in his brain after being diagnosed with an aggressive tumor called a glioblastoma. It's the same type of tumor that killed Sen. Edward M. Kennedy at age 77 in 2009.
McCain rebounded quickly, however, returning to Washington and entering the Senate in late July to a standing ovation from his colleagues. In a dramatic turn, he later cast a deciding vote against the Republican health care bill, earning the wrath of Trump, who frequently cites McCain's vote at campaign events.
McCain's condition worsened last fall and he has been in Arizona since December. A source close to McCain who asked not to be identified said Friday the senator was at his Arizona ranch with his family.
"This is a very difficult disease," said Michael Lawton, President and CEO of Barrow Neurological Institute. "It's horrible."
Lawton says it's impossible to pinpoint how much fight McCain has left in him.
"It could mean days, it could mean longer, weeks, or maybe a month. It's a decision that really represents reaching that end, and deciding how to prioritize the quality of life over the quantity of life."
McCain is a long-term survivor of melanoma, a deadly skin cancer. Doctors classified his brain cancer as a "primary tumor," meaning it's not related to his former malignancies.
McCain ran unsuccessfully for the Republican presidential nomination in 2000, then won it in 2008 before losing the general election to Obama.
He returned to the Senate, determined not to be defined by a failed presidential campaign in which his reputation as a maverick had faded.
When Republicans took control of the Senate in 2015, McCain, the scion in a decorated military family, embraced his new influence as chairman of the Senate Armed Services Committee, pushing for aggressive U.S. military intervention overseas and eager to contribute to "defeating the forces of radical Islam that want to destroy America."
Asked how he wanted to be remembered, McCain said simply: "That I made a major contribution to the defense of the nation."
Former Connecticut Sen. Joseph Lieberman, a close friend, said Friday that "becoming John McCain's friend has been one of the great blessings of my life. Today I am praying for him and his family."