J. Craig Venter, pioneer of human genome sequencing, dies at 79
Pioneering geneticist J. Craig Venter and a team from the J. Craig Venter Institute in La Jolla have designed and synthesized a minimal bacterial genome, consisting of 473 genes, the only genes necessary for life. | (K.C. Alfred/ San Diego Union-Trib
J. Craig Venter, a pioneer who produced the first draft of the human genome and advanced our understanding of how genes influence human life, died Wednesday at 79.
Venter’s death was announced by the J. Craig Venter Institute, a genomics research group with locations in La Jolla, California, and Rockville, Maryland. The institute said he died in San Diego after being hospitalized for side effects from a recent cancer treatment.
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In the 1990s Venter bet that he could use a different sequencing technique to speed up the process of decoding the human genome and beat an enormous government effort called the Human Genome Project. And in 2000, Venter’s private company Celera Genomics announced, along with Human Genome Project leaders, that they had decoded the 3.1 billion sub-units of DNA, the chemical "letters″ that make up the recipe of human life. Three years later, in April 2003, the project declared the genome complete.
"Some have said to me that sequencing the human genome will diminish humanity by taking the mystery out of life," Venter said at a White House event in 2000 about the breakthrough. "Nothing could be further from the truth."
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And his work did reveal even greater mysteries — even as it helped scientists understand the genetic causes for rare diseases and more common conditions such as heart disease and cancer, as well as what mutations or shifts may put people at higher risk of disease.
Venter, who served in the U.S. Navy during Vietnam, said the experience taught him how fragile life could be and made him curious about how the trillions of cells in the human body conspire to create and maintain life.
He also worked at the National Institutes of Health, where he helped develop a technique to quickly identify large swathes of human genes.
Later, he was the first to publish his own sequenced genome with the hope that researchers could scan it to learn what was inherited from each parent and where vulnerabilities to disease might lie, opening doors to one day tailor future treatments to a person's genes. He and his team also made a breakthrough in synthetic biology by creating a bacterial cell with lab-synthesized DNA.
The Source: The Associated Press contributed to this report. The information in this story comes primarily from the J. Craig Venter Institute, which announced his death and provided details about the circumstances. This story was reported from Los Angeles.