HHS eases restrictions on certain unapproved peptides
FILE-A sign is displayed at the entrance to the Department of Health and Human Services (HHS) headquarters at the Hubert H. Humphrey Building on June 2, 2025 in Washington, D.C. (Photo by Kevin Carter/Getty Images)
Health and Human Services is advancing a policy advancing licensed pharmacies and physicians to compound some unapproved peptides as regulators determine whether to allow their use in compounded medicines.
HHS Secretary Robert F. Kennedy has advocated for wider access to peptides and has hinted at the possibility of the Food and Drug Administration lifting restrictions on them.
HHS policy on unapproved peptides
Dig deeper:
Reuters reported that the federal agency’s policy allows compounding of six peptides, like BPC-157 and TB-500 — often taken together in a combination known as the "Wolverine stack" without concern of backlash from the Food and Drug Administration.
The other peptides are epitalon for insomnia, KPV for wound healing and inflammatory conditions, MOTS-c for obesity and osteoporosis, and Semax for migraines and persistent pain.
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Referencing the Health and Human Services policy, Reuters noted that the federal agency would not take enforcement action against compounders that manufacture some peptides if they meet standards on ingredient quality, manufacturing requirements, safety reporting, labeling and patient-specific prescriptions.
Peptides have gained popularity in the past year, in part with support from wellness influencers based on uses including anti-aging to muscle recovery and tissue repair.
What they're saying:
According to Reuters, HHS officials said the policy will deter the rampant use of certain research-use-only peptides supplied by foreign manufacturers that pose a safety risk to patients in the United States and improve patient access.
The agency added that "There is significant interest in the use of these peptides in compounding given the lack of approved products," describing it as an interim policy.
What are peptides?
Big picture view:
Peptides are short chains of amino acids in the body that perform essential functions. Dr. Melinda Ring, director of the Osher Center for Integrative Health at Northwestern University Feinberg School of Medicine, said the body naturally produces thousands of peptides, regulating "everything from hormone signaling to immune response and tissue repair."
The Source: Information for this story was provided by Reuters, which cites comments from Health and Human Services as the agency’s peptide policy and previous FOX Local reporting. This story was reported from Washington, D.C.