The crash happened around 3:30 a.m. Monday about 7 miles west of Winona, television station KAKE reported.
Raymond Kennedy, 45, of Glendale, Arizona, and Brenda Carrasco, 54, of Peoria, Arizona, were traveling eastbound in a Jeep Wrangler when it hit the cow and rolled several times, according to the Kansas Highway Patrol.
Both Kennedy and Carrasco were pronounced dead at the scene.
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