The Coast Guard seized the contraband from drug runners in the Caribbean, Atlantic Ocean, and parts of the Pacific Ocean.
The crew of the Coast Guard Cutter James brought the drugs to Port Everglades in Fort Lauderdale on Wednesday morning.
Officials said they seized approximately 23,000 pounds of cocaine and 8,800 pounds of marijuana in multiple interdictions. The drugs have are worth more than $411.3 million.
Aerial video from WSVN showed armed officers guarding the confiscated drugs onboard the vessel.